abstract：PURPOSE:Recovery of the most basic shoulder-flexion/elbow-extension components of functional reach is critical for effective arm function following stroke. In order to understand the mechanisms of motor recovery, it is important to characterize the pattern of brain activation during the reach task. METHODS:We evaluate...

journal_title：Restorative neurology and neuroscience

authors： Daly JJ,Hrovat K,Holcomb J,Pundik S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...

journal_title：Restorative neurology and neuroscience

authors： Szaflarski JP,Allendorfer JB,Byars AW,Vannest J,Dietz A,Hernando KA,Holland SK

更新日期：2014-01-01 00:00:00

abstract：:Although neurotransmitter-based hypotheses still prevail current thinking about the mechanism of action of psychotropic drugs, recent insight into the pathophysiology of psychiatric disorders has unveiled a range of new therapeutic actions of the drugs used to treat those disorders. Especially antidepressants seem to ...

journal_title：Restorative neurology and neuroscience

authors： Paulzen M,Veselinovic T,Gründer G

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The illusory ownership of a fake hand as part the body follows synchronous tactile stimulation over a visible rubber hand and a covered hand. Whether brain plasticity mechanisms after sensory and motor disconnection modulates this illusion remain unexplored. METHODS:We tested a tetraplegic man after synchronou...

journal_title：Restorative neurology and neuroscience

authors： Tidoni E,Grisoni L,Liuzza MT,Aglioti SM

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The effectiveness of embryonic stem cell (eSC) therapy has been explored in many models of neurological disease and several research groups have shown that eSC treatment leads to improved outcomes in pre-clinical models of traumatic brain injury (TBI). Though functional recovery occurs, few surviving eSCs appea...

journal_title：Restorative neurology and neuroscience

authors： Peruzzaro ST,Gallagher J,Dunkerson J,Fluharty S,Mudd D,Hoane MR,Smith JS

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:The present study was aimed to investigate whether combination treatment with progesterone and rehabilitation training would be more effective than monotherapy after cerebral ischemia. METHODS:C57BL/6 mice were subjected to focal ischemia by photothrombosis and were treated with progesterone (2 mg/kg), rehabil...

journal_title：Restorative neurology and neuroscience

authors： Wang J,Feng X,Du Y,Wang L,Zhang S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICI...

journal_title：Restorative neurology and neuroscience

authors： Min K,Song J,Lee JH,Kang MS,Jang SJ,Kim SH,Kim M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. METHODS:48 adult male rats underwent standardized crush injury of left...

journal_title：Restorative neurology and neuroscience

authors： Brown TJ,Pittman AL,Monaco GN,Benscoter BJ,Mantravadi AV,Akst LM,Jones KJ,Foecking EM

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...

journal_title：Restorative neurology and neuroscience

authors： Singer BJ,Vallence AM,Cleary S,Cooper I,Loftus AM

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of an...

journal_title：Restorative neurology and neuroscience

authors： Feeney EJ,Stephenson D,Kleiman R,Bove S,Cron C,Moody L,Robinson M,Ramirez JJ

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

journal_title：Restorative neurology and neuroscience

authors： Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Bacopa monnieri (L.) WETTST. is extensively used in traditional Indian medicine as a nerve tonic. The neuropharmacological properties of bacopaside I, an important component from B. monnieri, have not been studied so far. The present study investigated the effects and possible mechanisms of bacopaside I in a ra...

journal_title：Restorative neurology and neuroscience

authors： Liu X,Yue R,Zhang J,Shan L,Wang R,Zhang W

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. METHODS:Thirty-two ...

journal_title：Restorative neurology and neuroscience

authors： Wang T,Van KC,Gavitt BJ,Grayson JK,Lu YC,Lyeth BG,Pichakron KO

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

journal_title：Restorative neurology and neuroscience

authors： Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-...

journal_title：Restorative neurology and neuroscience

authors： Chen H,Dzitoyeva S,Manev H

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...

journal_title：Restorative neurology and neuroscience

authors： Bianco G,Feurra M,Fadiga L,Rossi A,Rossi S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...

journal_title：Restorative neurology and neuroscience

authors： Chang WH,Kim YH,Yoo WK,Goo KH,Park CH,Kim ST,Pascual-Leone A

更新日期：2012-01-01 00:00:00

abstract：:The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can...

journal_title：Restorative neurology and neuroscience

authors： Oliveri M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

journal_title：Restorative neurology and neuroscience

authors： Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Focal dystonia in musicians (MD) is a task-specific movement disorder with a loss of voluntary motor control during instrumental playing. Defective inhibition on different levels of the central nervous system is involved in the pathophysiology. Sensorimotor retraining is a therapeutic approach to MD and aims...

journal_title：Restorative neurology and neuroscience

authors： Buttkus F,Baur V,Jabusch HC,de la Cruz Gomez-Pellin M,Paulus W,Nitsche MA,Altenmüller E

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

journal_title：Restorative neurology and neuroscience

authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

更新日期：2011-01-01 00:00:00

abstract：:In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term wit...

journal_title：Restorative neurology and neuroscience

authors： Brandt T,Zwergal A,Jahn K,Strupp M

更新日期：2010-01-01 00:00:00

abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...

journal_title：Restorative neurology and neuroscience

authors： Todd G,Ridding MC

更新日期：2010-01-01 00:00:00

abstract：:Since various studies, including multi-centre studies, investigating the effect of repetitive transcranial magnetic stimulation (rTMS) in depression have shown different results, it is now important to research, which symptoms of depression are most responsive to this kind of non-invasive brain stimulation. Furthermor...

journal_title：Restorative neurology and neuroscience

authors： Höppner J,Berger C,Walter U,Padberg F,Buchmann J,Herwig U,Domes G

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Interacting with others by reading their emotional expressions is an essential social skill in humans. How this ability develops during infancy and what brain processes underpin infants' perception of emotion in different modalities are the questions dealt with in this paper. METHODS:Literature review. RESULT...

journal_title：Restorative neurology and neuroscience

authors： Grossmann T

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To assess whether insights from postural control without additional visual feedback (VFB) could be gained to explain the possible VFB effects (or non-effects) on upright stance performance. METHODS:The center-of-pressure (CP) displacements of 39 patients with a recent hemispheric stroke (93 days ± 56; mean ± s...

journal_title：Restorative neurology and neuroscience

authors： Rougier P,Boudrahem S

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The quality of presurgical evaluation in focal extratemporal epilepsy surgery is highly dependent on precise structural and functional identification of the epileptic focus. Navigated transcranial magnetic stimulation (nTMS) is a tool that combines the spatial information of high-resolution magnetic resonance i...

journal_title：Restorative neurology and neuroscience

authors： Schmidt S,Holst E,Irlbacher K,Oltmanns F,Merschhemke M,Brandt SA

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...

journal_title：Restorative neurology and neuroscience

authors： Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJ

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...

journal_title：Restorative neurology and neuroscience

authors： Luukkainen-Markkula R,Tarkka IM,Pitkänen K,Sivenius J,Hämäläinen H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:This article reviews the literature on far transfer effects in training of older adults. METHODS:Adapting a taxonomy of transfer developed by Barnett and Ceci (2002), to rehabilitation or enhancement of existing cognitive skills; results of studies assessing transfer effects from training of memory, reasoning,...

journal_title：Restorative neurology and neuroscience

authors： Zelinski EM

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Traumatic brain injury (TBI) -induced brain edema can be reduced by acute progesterone (PROG) treatment in young adult males and females, and in aged males. To extend these findings we tested these hypotheses: 1. Acute PROG treatment post-TBI will reduce cortical edema in aged females as much as in young adults...

journal_title：Restorative neurology and neuroscience

authors： Kasturi BS,Stein DG

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHOD...

journal_title：Restorative neurology and neuroscience

authors： Gall C,Mueller I,Gudlin J,Lindig A,Schlueter D,Jobke S,Franke GH,Sabel BA

更新日期：2008-01-01 00:00:00

abstract：:The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds...

journal_title：Restorative neurology and neuroscience

authors： Ruitenberg MJ,Vukovic J

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:The present study was designed to investigate the neural correlates of German Sign Language (Deutsche Gebärdensprache; DGS) processing. In particular, was expected the impact of the visuo-spatial mode in sign language on underlying neural networks compared to the impact of the interpretation of linguistic infor...

journal_title：Restorative neurology and neuroscience

authors： Meyer M,Toepel U,Keller J,Nussbaumer D,Zysset S,Friederici AD

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Several studies on auditory temporal-order processing showed gender differences. Women needed longer inter-stimulus intervals than men when indicating the temporal order of two clicks presented to the left and right ear. In this study, we examined whether we could reproduce these results in order to further inv...

journal_title：Restorative neurology and neuroscience

authors： van Kesteren MT,Wiersinga-Post JE

更新日期：2007-01-01 00:00:00

abstract：:Corticomotor excitability is reduced during rhythmic passive movement compared to rest, but it is not known whether the mechanism is purely segmental or includes a supraspinal pathway. To determine how interruption of sensory projections at a supraspinal level affects corticomotor excitability during passive movement,...

journal_title：Restorative neurology and neuroscience

authors： Edwards DJ,Mastaglia FL,Byrnes ML,Fregni F,Pascual-Leone A,Thickbroom GW

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Barth A,Guzman R,Andres RH,Mordasini P,Barth L,Widmer HR

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...

journal_title：Restorative neurology and neuroscience

authors： Petit L,Simon G,Joliot M,Andersson F,Bertin T,Zago L,Mellet E,Tzourio-Mazoyer N

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge. METHODS:Motor activity was encouraged through provision of motor enrichment housing (MEH); a mult...

journal_title：Restorative neurology and neuroscience

authors： Moon LD,Leasure JL,Gage FH,Bunge MB

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The interest in human conscious awareness has increasingly propelled the study of neglect, the most striking occurrence of an acquired lack of conscious experience of space. Neglect syndromes commonly arise after unilateral brain damage that spares primary sensory areas nonetheless leading to a lack of consciou...

journal_title：Restorative neurology and neuroscience

authors： Brozzoli C,Demattè ML,Pavani F,Frassinetti F,Farnè A

更新日期：2006-01-01 00:00:00